Ontology highlight
ABSTRACT:
SUBMITTER: Wolf C
PROVIDER: S-EPMC2531286 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Wolf Christian C Liu Shuanglong S Mei Xuefeng X August Adam T AT Casimir Michael D MD
The Journal of organic chemistry 20060401 8
A chemo- and regioselective copper-catalyzed cross-coupling procedure for amination of 2-bromobenzoic acids is described. The method eliminates the need for acid protection and produces N-aryl and N-alkyl anthranilic acid derivatives in up to 99% yield. N-(1-Pyrene)anthranilic acid has been employed in metal ion-selective fluorosensing. Titration experiments showed that this pyrene-derived amino acid forms an equimolar complex with Hg(II) in water resulting in selective fluorescence quenching ev ...[more]