Synthesis of nitric oxide reductase active site models bearing key components at both distal and proximal sites.
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ABSTRACT:
SUBMITTER: Collman JP
PROVIDER: S-EPMC2532532 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
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Synthesis of nitric oxide reductase active site models bearing key components at both distal and proximal sites.
Collman James P JP Yang Ying Y Decréau Richard A RA
Organic letters 20070620 15
Porphyrins 1ab and 2ab were successfully synthesized from cis-alpha2-bisimidazole-beta-imidazole-tail porphyrins and two newly synthesized imidazole pickets containing an aliphatic ester chain following a [2+1] approach. The four compounds possess a distal trisimidazole set, a distal carboxylic acid, and a proximal imidazole, which constitute all the key features of the coordination environment of the active site in Bacterial Nitric Oxide Reductase (NOR) and make them the closest synthetic NOR m ...[more]
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