Ontology highlight
ABSTRACT:
SUBMITTER: Parone PA
PROVIDER: S-EPMC2532749 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Parone Philippe A PA Da Cruz Sandrine S Tondera Daniel D Mattenberger Yves Y James Dominic I DI Maechler Pierre P Barja François F Martinou Jean-Claude JC
PloS one 20080922 9
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventing mitochondrial fission, by down-regulating expression of Drp1 in mammalian cells leads to a loss of mitochondrial DNA and a decrease of mitochondrial respiration coupled to an increase in the levels of cellular reactive oxygen species (ROS). At the ...[more]