Ontology highlight
ABSTRACT:
SUBMITTER: Weisz ED
PROVIDER: S-EPMC5886180 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Weisz Eliana D ED Towheed Atif A Monyak Rachel E RE Toth Meridith S MS Wallace Douglas C DC Jongens Thomas A TA
Human molecular genetics 20180101 1
Fragile X Syndrome (FXS), the most prevalent form of inherited intellectual disability and the foremost monogenetic cause of autism, is caused by loss of expression of the FMR1 gene . Here, we show that dfmr1 modulates the global metabolome in Drosophila. Despite our previous discovery of increased brain insulin signaling, our results indicate that dfmr1 mutants have reduced carbohydrate and lipid stores and are hypersensitive to starvation stress. The observed metabolic deficits cannot be expla ...[more]