Evolutionary trace analysis at the ligand binding site of laccase.
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ABSTRACT:
SUBMITTER: Mohamad SB
PROVIDER: S-EPMC2533054 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Publications
Evolutionary trace analysis at the ligand binding site of laccase.
Mohamad Saharuddin Bin SB Ong Ai Ling AL Ripen Adiratna Mat AM
Bioinformation 20080618 9
Laccase belongs to the family of blue multi-copper oxidases and are capable of oxidizing a wide range of aromatic compounds. Laccases have industrial applications in paper pulping or bleaching and hydrocarbon bioremediation as a biocatalyst. We describe the design of a laccase with broader substrate spectrum in bioremediation. The application of evolutionary trace (ET) analysis of laccase at the ligand binding site for optimal design of the enzyme is described. In this attempt, class specific si ...[more]
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