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Oligomannan synthesis using ionic liquid supported glycosylation.

ABSTRACT: The synthesis of complex oligosaccharides has been a challenge for researchers. Herein, we describe a strategy for the synthesis of an activated oligomannan 1 that employs ionic liquid (IL) support glycosylation methodology on an IL-tagged mannosyl fluoride donor. This method is capable of rapidly producing linear alpha(1-->6) oligomannan thioglycosides in a convenient and cost-effective manner without the need of column purification after each glycosylation step.

SUBMITTER: Pathak AK

PROVIDER: S-EPMC2533115 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Oligomannan synthesis using ionic liquid supported glycosylation.

Pathak Ashish K AK Yerneni Charu K CK Young Zac Z Pathak Vibha V

Organic letters 20071211 1

The synthesis of complex oligosaccharides has been a challenge for researchers. Herein, we describe a strategy for the synthesis of an activated oligomannan 1 that employs ionic liquid (IL) support glycosylation methodology on an IL-tagged mannosyl fluoride donor. This method is capable of rapidly producing linear alpha(1-->6) oligomannan thioglycosides in a convenient and cost-effective manner without the need of column purification after each glycosylation step. ...[more]

PMID: 18069846

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