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Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest.


ABSTRACT: Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively.

SUBMITTER: Hou Y 

PROVIDER: S-EPMC2533136 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest.

Hou Yanpeng Y   Cao Shugeng S   Brodie Peggy P   Miller James S JS   Birkinshaw Chris C   Ratovoson Fidisoa F   Rakotondrajaona Roland R   Andriantsiferana Rabodo R   Rasamison Vincent E VE   Kingston David G I DG  

Journal of natural products 20071229 1


Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative acti  ...[more]

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