Unexpected acetylcholinesterase activity of cocaine esterases.
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ABSTRACT:
SUBMITTER: Rogers CJ
PROVIDER: S-EPMC2533137 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
Unexpected acetylcholinesterase activity of cocaine esterases.
Rogers Claude J CJ Eubanks Lisa M LM Dickerson Tobin J TJ Janda Kim D KD
Journal of the American Chemical Society 20061201 48
A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases. ...[more]
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