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Synthesis of an advanced intermediate en route to the mitomycin natural products.

ABSTRACT: [Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation.

SUBMITTER: Williams AL

PROVIDER: S-EPMC2533355 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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Synthesis of an advanced intermediate en route to the mitomycin natural products.

Williams Amie L AL Srinivasan Jayasree M JM Johnston Jeffrey N JN

Organic letters 20061201 26

[Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation. ...[more]

PMID: 17165926

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