Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: Mesak LR
PROVIDER: S-EPMC2533449 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
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Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
Mesak Lili Rosana LR Miao Vivian V Davies Julian J
Antimicrobial agents and chemotherapy 20080630 9
Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants. ...[more]
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