Ontology highlight
ABSTRACT:
SUBMITTER: Omori E
PROVIDER: S-EPMC2533783 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Omori Emily E Morioka Sho S Matsumoto Kunihiro K Ninomiya-Tsuji Jun J
The Journal of biological chemistry 20080707 38
Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the mechanisms underlying this hypersensitivity. We found that TAK1 deficiency up-regulates reactive oxygen species (ROS) resulting in cell death upon TNF or oxidative stress challenge. Because blockade of NF-kappaB did not increase ROS or did not sensitize cells to oxidative stress in keratinocytes TAK1 regulates ROS mainly thr ...[more]