Ontology highlight
ABSTRACT:
SUBMITTER: Sakamachi Y
PROVIDER: S-EPMC5386472 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Sakamachi Yosuke Y Morioka Sho S Mihaly September R SR Takaesu Giichi G Foley Julie F JF Fessler Michael B MB Ninomiya-Tsuji Jun J
Cell death & disease 20170209 2
Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1<sup>HKO</sup>) caused accumulation of cellular debris in the thymus in perinatal mice. Although no overt alteration in thymocytes and blood myeloid populations was observed in Tak1<sup>HKO</sup> mice, we found that thym ...[more]