Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.
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ABSTRACT:
SUBMITTER: Whitson EL
PROVIDER: S-EPMC2533843 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
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Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.
Whitson Emily L EL Mala S M V Damayanthi SM Veltri Charles A CA Bugni Tim S TS de Silva E Dilip ED Ireland Chris M CM
Journal of natural products 20061201 12
Two new sesquiterpene pyridine alkaloids, oppositines A (1) and B (2), have been isolated from the plant Pleurostylia opposita, collected in Sri Lanka. The compounds were isolated and purified by solvent/solvent partitioning, column chromatography, and HPLC. Their structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Oppositines A (1) and B (2) showed moderate cytotoxicity against HCT116 cell lines with EC50 values of 27 +/- 2 and 26 +/- 3 micro ...[more]
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