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Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii.

ABSTRACT: Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 ?M.

SUBMITTER: Fan D

PROVIDER: S-EPMC6273108 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii.

Fan Dongsheng D Zhu Guo-Yuan GY Li Ting T Jiang Zhi-Hong ZH Bai Li-Ping LP

Molecules (Basel, Switzerland) 20160829 9

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second m ...[more]

PMID: 27589701

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