Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues.
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ABSTRACT:
SUBMITTER: Ratnayake AS
PROVIDER: S-EPMC2533845 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
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Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues.
Ratnayake Anokha S AS Bugni Tim S TS Veltri Charles A CA Skalicky Jack J JJ Ireland Chris M CM
Organic letters 20060501 10
[reaction: see text] Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A(2) derivatives (6a-6c) has been accomplished. (15S)-Prostaglandin-A(2) (1), from the gorgonian Plexaura homomalla, served as the starting material for the synthesis. The absolute configuration was determined using NMR. ...[more]
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