Inhibition of prostaglandin biosynthesis by 7-oxa- and 5-oxa-prostaglandin analogues.
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ABSTRACT: Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure-activity relationships were ascertained.
SUBMITTER: McDonald-Gibson RG
PROVIDER: S-EPMC1177566 | biostudies-other | 1973 Jan
REPOSITORIES: biostudies-other
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