Ontology highlight
ABSTRACT:
SUBMITTER: Silva GL
PROVIDER: S-EPMC2535610 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Silva Gloria L GL Ediz Volkan V Yaron David D Armitage Bruce A BA
Journal of the American Chemical Society 20070406 17
Unsymmetrical cyanine dyes are widely used in biomolecular detection due to their fluorogenic behavior, whereby fluorescence quantum yields can be very low in fluid solution but are significantly enhanced in conformationally restricted environments. Herein we describe a series of fluorinated analogues of the dye thiazole orange that exhibit improved fluorescence quantum yields and photostabilities. In addition, computational studies on these dyes revealed that twisting about the monomethine brid ...[more]