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Suppression of aging in mice by the hormone Klotho.

ABSTRACT: A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.

SUBMITTER: Kurosu H

PROVIDER: S-EPMC2536606 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Suppression of aging in mice by the hormone Klotho.

Kurosu Hiroshi H Yamamoto Masaya M Clark Jeremy D JD Pastor Johanne V JV Nandi Animesh A Gurnani Prem P McGuinness Owen P OP Chikuda Hirotaka H Yamaguchi Masayuki M Kawaguchi Hiroshi H Shimomura Iichiro I Takayama Yoshiharu Y Herz Joachim J Kahn C Ronald CR Rosenblatt Kevin P KP Kuro-o Makoto M

Science (New York, N.Y.) 20050825 5742

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by pertur ...[more]

PMID: 16123266

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