Ontology highlight
ABSTRACT:
SUBMITTER: Visser WE
PROVIDER: S-EPMC4783069 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Visser W Edward WE Bombardieri Cíntia R CR Zevenbergen Chantal C Barnhoorn Sander S Ottaviani Alexandre A van der Pluijm Ingrid I Brandt Renata R Kaptein Ellen E van Heerebeek Ramona R van Toor Hans H Garinis George A GA Peeters Robin P RP Medici Marco M van Ham Willy W Vermeij Wilbert P WP de Waard Monique C MC de Krijger Ronald R RR Boelen Anita A Kwakkel Joan J Kopchick John J JJ List Edward O EO Melis Joost P M JP Darras Veerle M VM Dollé Martijn E T ME van der Horst Gijsbertus T J GT Hoeijmakers Jan H J JH Visser Theo J TJ
PloS one 20160308 3
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespread effects. Here, we reveal a significant common transcriptomic signature in livers from hypothyroid mice, DNA repair-deficient mice with severe (Csbm/m/Xpa-/-) or intermediate (Ercc1-/Δ-7) progeria a ...[more]