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Asymmetric synthesis of trans-2,5-disubstituted pyrrolidines from enantiopure homoallylic amines. Synthesis of pyrrolidine (-)-197B.

ABSTRACT: Iodocyclization of sulfinimine-derived enantiopure homoallylic sulfonamides affords trans-2,5-disubstituted 3-iodopyrrolidines and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring system.

SUBMITTER: Davis FA

PROVIDER: S-EPMC2536609 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of trans-2,5-disubstituted pyrrolidines from enantiopure homoallylic amines. Synthesis of pyrrolidine (-)-197B.

Davis Franklin A FA Song Minsoo M Augustine Alexander A

The Journal of organic chemistry 20060301 7

Iodocyclization of sulfinimine-derived enantiopure homoallylic sulfonamides affords trans-2,5-disubstituted 3-iodopyrrolidines and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring system. ...[more]

PMID: 16555832

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