Ontology highlight
ABSTRACT:
SUBMITTER: Lemen GS
PROVIDER: S-EPMC2873168 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Lemen Georgia S GS Wolfe John P JP
Organic letters 20100501 10
Palladium-catalyzed carboamination reactions between aryl bromides and 4-(but-3-enyl)-substituted oxazolidin-2-ones are described. These transformations afford bicyclic oxazolidin-2-one derivatives that can be converted to trans-2,5-disubstituted pyrrolidines in one step. The starting materials are easily prepared from amino acid precursors, and products that contain up to three stereocenters are generated with >20:1 dr. ...[more]