Systems biology approach to identification of biomarkers for metastatic progression in cancer.
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ABSTRACT:
SUBMITTER: Ptitsyn AA
PROVIDER: S-EPMC2537559 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Systems biology approach to identification of biomarkers for metastatic progression in cancer.
Ptitsyn Andrey A AA Weil Michael M MM Thamm Douglas H DH
BMC bioinformatics 20080812
<h4>Background</h4>Metastases are responsible for the majority of cancer fatalities. The molecular mechanisms governing metastasis are poorly understood, hindering early diagnosis and treatment. Previous studies of gene expression patterns in metastasis have concentrated on selection of a small number of "signature" biomarkers.<h4>Results</h4>We propose an alternative approach that puts into focus gene interaction networks and molecular pathways rather than separate genes. We have reanalyzed exp ...[more]
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