Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data.

ABSTRACT:

Background

Molecular signaling of angiogenesis begins within hours after initiation of a stroke and the following regulation of endothelial integrity mediated by growth factor receptors and vascular growth factors. Recent studies further provided insights into the coordinated patterns of post-stroke gene expressions and the relationships between neurodegenerative diseases and neural function recovery processes after a stroke.

Results

Differential protein-protein interaction networks (PPINs) were constructed at 3 post-stroke time points, and proteins with a significant stroke relevance value (SRV) were discovered. Genes, including UBC, CUL3, APP, NEDD8, JUP, and SIRT7, showed high associations with time after a stroke, and Ingenuity Pathway Analysis results showed that these

SUBMITTER: Wong YH 

PROVIDER: S-EPMC4674888 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature