Ontology highlight
ABSTRACT:
SUBMITTER: Yudin D
PROVIDER: S-EPMC2538677 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Yudin Dmitry D Hanz Shlomit S Yoo Soonmoon S Iavnilovitch Elena E Willis Dianna D Gradus Tal T Vuppalanchi Deepika D Segal-Ruder Yael Y Ben-Yaakov Keren K Hieda Miki M Yoneda Yoshihiro Y Twiss Jeffery L JL Fainzilber Mike M
Neuron 20080701 2
Peripheral sensory neurons respond to axon injury by activating an importin-dependent retrograde signaling mechanism. How is this mechanism regulated? Here, we show that Ran GTPase and its associated effectors RanBP1 and RanGAP regulate the formation of importin signaling complexes in injured axons. A gradient of nuclear RanGTP versus cytoplasmic RanGDP is thought to be fundamental for the organization of eukaryotic cells. Surprisingly, we find RanGTP in sciatic nerve axoplasm, distant from neur ...[more]