Ontology highlight
ABSTRACT:
SUBMITTER: Terenzio M
PROVIDER: S-EPMC6501578 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Terenzio Marco M Koley Sandip S Samra Nitzan N Rishal Ida I Zhao Qian Q Sahoo Pabitra K PK Urisman Anatoly A Marvaldi Letizia L Oses-Prieto Juan A JA Forester Craig C Gomes Cynthia C Kalinski Ashley L AL Di Pizio Agostina A Doron-Mandel Ella E Perry Rotem Ben-Tov RB Koppel Indrek I Twiss Jeffery L JL Burlingame Alma L AL Fainzilber Mike M
Science (New York, N.Y.) 20180301 6382
How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA). This mRNA was transported into axons by the cell size-regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local translation in injured axons. This included regulation of its own translation and that of retrograde injury signaling molecules such as importin β1 an ...[more]