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Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.

ABSTRACT: Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of 1 were confirmed by single-crystal X-ray diffraction. Compound 3 showed moderate activity in the A2780 human ovarian cancer cell line, with an IC50 of 3.3 microM.

SUBMITTER: Williams RB

PROVIDER: S-EPMC2539064 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.

Williams Russell B RB Norris Andrew A Slebodnick Carla C Merola Joseph J Miller James S JS Andriantsiferana Rabodo R Rasamison Vincent E VE Kingston David G I DG

Journal of natural products 20050901 9

Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of 1 were confirmed by single-crystal X-ray diffraction. Compound 3 showed moderate activity in the A2780 human ovarian cancer cell line, with an IC50 of 3.3 microM. ...[more]

PMID: 16180816

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