Ontology highlight
ABSTRACT:
SUBMITTER: Williams RB
PROVIDER: S-EPMC2539064 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Journal of natural products 20050901 9
Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of 1 were confirmed by single-crystal X-ray diffraction. Compound 3 showed moderate activity in the A2780 human ovarian cancer cell line, with an IC50 of 3.3 microM. ...[more]