Unknown

Dataset Information

0

Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea.


ABSTRACT: Four new sesquiterpene lactones, 8?-(2'Z-tigloyloxy)-hirsutinolide (1), 8?-(2'Z-tigloyloxy)-hirsutinolide-13-O-acetate (2), 8?-(4-hydroxytigloyloxy)-hirsutinolide (3), and 8?-hydroxy-13-O-tigloyl-hirsutinolide (4), along with seven known derivatives (5-11), three norisoprenoids (12-14), a flavonoid (15), and a linoleic acid derivative (16), were isolated from the chloroform partition of a methanol extract from the combined leaves and stems of Vernonia cinerea. Their structures were established by 1D and 2D NMR, UV, and MS analyses. Compounds 1-16 were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbour aberrantly-active STAT3, compared to normal NIH3T3 mouse fibroblasts that show no evidence of activated STAT3. Among the isolates, compounds 2 and 7 inhibited the aberrant STAT3 activity in glioblastoma or breast cancer cells. Further, compounds 7 and 8 inhibited viability of all three cell lines, compounds 2, 4, and 9 predominantly inhibited the viability of the U251MG glioblastoma cell line.

SUBMITTER: Youn UJ 

PROVIDER: S-EPMC4038271 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea.

Youn Ui Joung UJ   Miklossy Gabriella G   Chai Xingyun X   Wongwiwatthananukit Supakit S   Toyama Onoomar O   Songsak Thanapat T   Turkson James J   Chang Leng Chee LC  

Fitoterapia 20131224


Four new sesquiterpene lactones, 8α-(2'Z-tigloyloxy)-hirsutinolide (1), 8α-(2'Z-tigloyloxy)-hirsutinolide-13-O-acetate (2), 8α-(4-hydroxytigloyloxy)-hirsutinolide (3), and 8α-hydroxy-13-O-tigloyl-hirsutinolide (4), along with seven known derivatives (5-11), three norisoprenoids (12-14), a flavonoid (15), and a linoleic acid derivative (16), were isolated from the chloroform partition of a methanol extract from the combined leaves and stems of Vernonia cinerea. Their structures were established b  ...[more]

Similar Datasets

| S-EPMC2539064 | biostudies-literature
| S-EPMC6154322 | biostudies-literature
| S-EPMC6009911 | biostudies-literature
| S-EPMC6400766 | biostudies-literature
| S-EPMC6017816 | biostudies-other
| S-EPMC8300741 | biostudies-literature
| S-EPMC7248990 | biostudies-literature
| S-EPMC6117149 | biostudies-literature
| S-EPMC4910329 | biostudies-literature
| S-EPMC8038342 | biostudies-literature