Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC2542477 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Wang Haibo H Tewari Ambika A Einheber Steven S Salzer James L JL Melendez-Vasquez Carmen V CV
The Journal of cell biology 20080915 6
The myelin sheath forms by the spiral wrapping of a glial membrane around the axon. The mechanisms responsible for this process are unknown but are likely to involve coordinated changes in the glial cell cytoskeleton. We have found that inhibition of myosin II, a key regulator of actin cytoskeleton dynamics, has remarkably opposite effects on myelin formation by Schwann cells (SC) and oligodendrocytes (OL). Myosin II is necessary for initial interactions between SC and axons, and its inhibition ...[more]