Ontology highlight
ABSTRACT:
SUBMITTER: Noseda R
PROVIDER: S-EPMC4829179 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Noseda Roberta R Guerrero-Valero Marta M Alberizzi Valeria V Previtali Stefano C SC Sherman Diane L DL Palmisano Marilena M Huganir Richard L RL Nave Klaus-Armin KA Cuenda Ana A Feltri Maria Laura ML Brophy Peter J PJ Bolino Alessandra A
PLoS biology 20160412 4
Microtubule-based kinesin motors have many cellular functions, including the transport of a variety of cargos. However, unconventional roles have recently emerged, and kinesins have also been reported to act as scaffolding proteins and signaling molecules. In this work, we further extend the notion of unconventional functions for kinesin motor proteins, and we propose that Kif13b kinesin acts as a signaling molecule regulating peripheral nervous system (PNS) and central nervous system (CNS) myel ...[more]