The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.
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ABSTRACT:
SUBMITTER: Paige C
PROVIDER: S-EPMC2546792 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.
Paige Carleitta C Reid Sean D SD Hanna Philip C PC Claiborne Al A
Journal of bacteriology 20080718 18
In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target. ...[more]
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