Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC2547035 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.
Zhang Weiping W Robertson Donald C DC Zhang Chengxian C Bai Wei W Zhao Mojun M Francis David H DH
Applied and environmental microbiology 20080725 18
To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins. ...[more]
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