Ontology highlight
ABSTRACT:
SUBMITTER: Mitra A
PROVIDER: S-EPMC2547448 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Biophysical journal 20080711 7
Taxol is a commonly used antitumor agent that hyperstabilizes microtubules and prevents cell division. The interaction of Taxol with tubulin and the microtubule has been studied through a wide array of experimental techniques; however, the exact molecular mechanism by which Taxol stabilizes microtubules has remained elusive. In this study, through the use of large-scale molecular simulations, we show that Taxol affects the interactions between the M and H1-S2 loops of adjacent tubulin dimers lea ...[more]