Ontology highlight
ABSTRACT:
SUBMITTER: Barnard TJ
PROVIDER: S-EPMC2551741 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Barnard Travis J TJ Dautin Nathalie N Lukacik Petra P Bernstein Harris D HD Buchanan Susan K SK
Nature structural & molecular biology 20071111 12
Autotransporters are virulence factors produced by Gram-negative bacteria. They consist of two domains, an N-terminal 'passenger' domain and a C-terminal beta-domain. beta-domains form beta-barrel structures in the outer membrane while passenger domains are translocated into the extracellular space. In some autotransporters, the two domains are separated by proteolytic cleavage. Using X-ray crystallography, we solved the 2.7-A structure of the post-cleavage state of the beta-domain of EspP, an a ...[more]