Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis.
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ABSTRACT:
SUBMITTER: Raychaudhuri S
PROVIDER: S-EPMC2553141 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis.
Raychaudhuri Subhadip S Raychaudhuri Subhadip S Willgohs Eric E Nguyen Thuc-Nghi TN Khan Elaine M EM Goldkorn Tzipora T
Biophysical journal 20080718 8
Apoptosis, or genetically programmed cell death, is a crucial cellular process that maintains the balance between life and death in cells. The precise molecular mechanism of apoptosis signaling and the manner in which type 1 and type 2 pathways of the apoptosis signaling network are differentially activated under distinct apoptotic stimuli is poorly understood. Based on Monte Carlo stochastic simulations, we show that the type 1 pathway becomes activated under strong apoptotic stimuli, whereas t ...[more]
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