Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC2553242 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Xu Jingsong J Gao Xiao-Pei XP Ramchandran Ramaswamy R Zhao You-Yang YY Vogel Stephen M SM Malik Asrar B AB
Nature immunology 20080629 8
Nonmuscle myosin light-chain kinase (MYLK) mediates increased lung vascular endothelial permeability in lipopolysaccharide-induced lung inflammatory injury, the chief cause of the acute respiratory distress syndrome. In a lung injury model, we demonstrate here that MYLK was also essential for neutrophil transmigration, but that this function was mostly independent of myosin II regulatory light chain, the only known substrate of MYLK. Instead, MYLK in neutrophils was required for the recruitment ...[more]