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Remarkably mild and efficient intramolecular Friedel-Crafts cyclization catalyzed by In(III).

ABSTRACT: [structure: see text]. Indium(III) salts were found to be highly effective catalysts for the intramolecular Friedel-Crafts reaction of simple allylic bromides and arenes. In(III) salts appear to be the most general and possess unique halophilic properties as a Lewis acid for this reaction among the catalysts evaluated to date. Deactivated arenes possessing chloride, bromide, and fluoride underwent smooth reaction when activated by InCl3.

SUBMITTER: Hayashi R

PROVIDER: S-EPMC2553353 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Remarkably mild and efficient intramolecular Friedel-Crafts cyclization catalyzed by In(III).

Hayashi Ryuji R Cook Gregory R GR

Organic letters 20070309 7

[structure: see text]. Indium(III) salts were found to be highly effective catalysts for the intramolecular Friedel-Crafts reaction of simple allylic bromides and arenes. In(III) salts appear to be the most general and possess unique halophilic properties as a Lewis acid for this reaction among the catalysts evaluated to date. Deactivated arenes possessing chloride, bromide, and fluoride underwent smooth reaction when activated by InCl3. ...[more]

PMID: 17346056

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