Ontology highlight
ABSTRACT:
SUBMITTER: Tonikian R
PROVIDER: S-EPMC2553845 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Tonikian Raffi R Zhang Yingnan Y Sazinsky Stephen L SL Currell Bridget B Yeh Jung-Hua JH Reva Boris B Held Heike A HA Appleton Brent A BA Evangelista Marie M Wu Yan Y Xin Xiaofeng X Chan Andrew C AC Seshagiri Somasekar S Lasky Laurence A LA Sander Chris C Boone Charles C Bader Gary D GD Sidhu Sachdev S SS
PLoS biology 20080901 9
PDZ domains are protein-protein interaction modules that recognize specific C-terminal sequences to assemble protein complexes in multicellular organisms. By scanning billions of random peptides, we accurately map binding specificity for approximately half of the over 330 PDZ domains in the human and Caenorhabditis elegans proteomes. The domains recognize features of the last seven ligand positions, and we find 16 distinct specificity classes conserved from worm to human, significantly extending ...[more]