Ontology highlight
ABSTRACT:
SUBMITTER: Altieri SL
PROVIDER: S-EPMC2555981 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Altieri Stephen L SL Clayton Gina M GM Silverman William R WR Olivares Adrian O AO De la Cruz Enrique M EM Thomas Lise R LR Morais-Cabral João H JH
Journal of molecular biology 20080610 3
MlotiK1 is a prokaryotic homolog of cyclic-nucleotide-dependent ion channels that contains an intracellular C-terminal cyclic nucleotide binding (CNB) domain. X-ray structures of the CNB domain have been solved in the absence of ligand and bound to cAMP. Both the full-length channel and CNB domain fragment are easily expressed and purified, making MlotiK1 a useful model system for dissecting activation by ligand binding. We have used X-ray crystallography to determine three new MlotiK1 CNB domai ...[more]