Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.
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ABSTRACT:
SUBMITTER: Heikaus CC
PROVIDER: S-EPMC2801740 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.
Heikaus Clemens C CC Pandit Jayvardhan J Klevit Rachel E RE
Structure (London, England : 1993) 20091201 12
GAF domains regulate the catalytic activity of certain vertebrate cyclic nucleotide phosphodiesterases (PDEs) by allosteric, noncatalytic binding of cyclic nucleotides. GAF domains arranged in tandem are found in PDE2, -5, -6, -10, and -11, all of which regulate the cellular concentrations of the second messengers cAMP and/or cGMP. Nucleotide binding to GAF domains affects the overall conformation and the catalytic activity of full-length PDEs. The cyclic nucleotide-bound GAF domains from PDE2, ...[more]
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