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Polymorphism of human telomeric quadruplex structures.

ABSTRACT: Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

SUBMITTER: Dai J

PROVIDER: S-EPMC2556180 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Polymorphism of human telomeric quadruplex structures.

Dai Jixun J Carver Megan M Yang Danzhou D

Biochimie 20080308 8

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important fo ...[more]

PMID: 18373984

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