Ontology highlight
ABSTRACT:
SUBMITTER: Huyghe JR
PROVIDER: S-EPMC2556434 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Huyghe Jeroen R JR Van Laer Lut L Hendrickx Jan-Jaap JJ Fransen Erik E Demeester Kelly K Topsakal Vedat V Kunst Sylvia S Manninen Minna M Jensen Mona M Bonaconsa Amanda A Mazzoli Manuela M Baur Manuela M Hannula Samuli S Mäki-Torkko Elina E Espeso Angeles A Van Eyken Els E Flaquer Antonia A Becker Christian C Stephens Dafydd D Sorri Martti M Orzan Eva E Bille Michael M Parving Agnete A Pyykkö Ilmari I Cremers Cor W R J CW Kremer Hannie H Van de Heyning Paul H PH Wienker Thomas F TF Nürnberg Peter P Pfister Markus M Van Camp Guy G
American journal of human genetics 20080828 3
Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype whil ...[more]