Ontology highlight
ABSTRACT:
SUBMITTER: Tenesa A
PROVIDER: S-EPMC2778004 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tenesa Albert A Farrington Susan M SM Prendergast James G D JG Porteous Mary E ME Walker Marion M Haq Naila N Barnetson Rebecca A RA Theodoratou Evropi E Cetnarskyj Roseanne R Cartwright Nicola N Semple Colin C Clark Andrew J AJ Reid Fiona J L FJ Smith Lorna A LA Kavoussanakis Kostas K Koessler Thibaud T Pharoah Paul D P PD Buch Stephan S Schafmayer Clemens C Tepel Jürgen J Schreiber Stefan S Völzke Henry H Schmidt Carsten O CO Hampe Jochen J Chang-Claude Jenny J Hoffmeister Michael M Brenner Hermann H Wilkening Stefan S Canzian Federico F Capella Gabriel G Moreno Victor V Deary Ian J IJ Starr John M JM Tomlinson Ian P M IP Kemp Zoe Z Howarth Kimberley K Carvajal-Carmona Luis L Webb Emily E Broderick Peter P Vijayakrishnan Jayaram J Houlston Richard S RS Rennert Gad G Ballinger Dennis D Rozek Laura L Gruber Stephen B SB Matsuda Koichi K Kidokoro Tomohide T Nakamura Yusuke Y Zanke Brent W BW Greenwood Celia M T CM Rangrej Jagadish J Kustra Rafal R Montpetit Alexandre A Hudson Thomas J TJ Gallinger Steven S Campbell Harry H Dunlop Malcolm G MG
Nature genetics 20080330 5
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802842 ...[more]