Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
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ABSTRACT:
SUBMITTER: Okubadejo N
PROVIDER: S-EPMC2559870 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
Okubadejo Njideka N Britton Angela A Crews Cynthia C Akinyemi Rufus R Hardy John J Singleton Andrew A Bras Jose J
PloS one 20081017 10
Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were fou ...[more]
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