Ontology highlight
ABSTRACT:
SUBMITTER: Yiu G
PROVIDER: S-EPMC2562229 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Yiu Gloria G McCord Alejandra A Wise Alison A Jindal Rishi R Hardee Jennifer J Kuo Allen A Shimogawa Michelle Yuen MY Cahoon Laty L Wu Michelle M Kloke John J Hardin Johanna J Mays Hoopes Laura L LL
The journals of gerontology. Series A, Biological sciences and medical sciences 20080101 1
Yeast replicative aging is a process resembling replicative aging in mammalian cells. During aging, wild-type haploid yeast cells enlarge, become sterile, and undergo nucleolar enlargement and fragmentation; we sought gene expression changes during the time of these phenotypic changes. Gene expression studied via microarrays and quantitative real-time reverse-transcription polymerase chain reaction (qPCR) has shown reproducible, statistically significant changes in messenger RNA (mRNA) of genes ...[more]