Ontology highlight
ABSTRACT:
SUBMITTER: Jolivet P
PROVIDER: S-EPMC6372760 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Jolivet Pascale P Serhal Kamar K Graf Marco M Eberhard Stephan S Xu Zhou Z Luke Brian B Teixeira Maria Teresa MT
Scientific reports 20190212 1
In eukaryotes, telomeres determine cell proliferation potential by triggering replicative senescence in the absence of telomerase. In Saccharomyces cerevisiae, senescence is mainly dictated by the first telomere that reaches a critically short length, activating a DNA-damage-like response. How the corresponding signaling is modulated by the telomeric structure and context is largely unknown. Here we investigated how subtelomeric elements of the shortest telomere in a telomerase-negative cell inf ...[more]