Ontology highlight
ABSTRACT:
SUBMITTER: LaFrate AL
PROVIDER: S-EPMC2562335 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20070927 22
5,6-dihydro-5-fluorouracil (5-DHFU) is a metabolite of the chemotherapy drug 5-fluorouracil (5-FU) of importance for biological studies. 5-DHFU has been prepared by enzymatic reduction of 5-FU and in very low yield by hydrogenation of 5-FU; however, a practical chemical synthesis is not available. Facile racemic syntheses of 5-DHFU from 5-FU or uracil, using p-methoxybenzyl protecting groups followed by L-Selectride reduction, are reported. ...[more]