Ontology highlight
ABSTRACT:
SUBMITTER: Huysamen C
PROVIDER: S-EPMC2562446 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Huysamen Cristal C Willment Janet A JA Dennehy Kevin M KM Brown Gordon D GD
The Journal of biological chemistry 20080411 24
We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the "Dectin-1 cluster" of related receptors, which are encoded within the natural killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3(+) dendritic cells and on a small subset of CD14(+)CD16(-) monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9 ...[more]