Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ralf Schittenhelm
LAB HEAD: Mireille Lahoud
PROVIDER: PXD018926 | Pride | 2020-11-27
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 8 |
Tullett Kirsteen M KM Tan Peck Szee PS Park Hae-Young HY Schittenhelm Ralf B RB Michael Nicole N Li Rong R Policheni Antonia N AN Gruber Emily E Huang Cheng C Fulcher Alex J AJ Danne Jillian C JC Czabotar Peter E PE Wakim Linda M LM Mintern Justine D JD Ramm Georg G Radford Kristen J KJ Caminschi Irina I O'Keeffe Meredith M Villadangos Jose A JA Wright Mark D MD Blewitt Marnie E ME Heath William R WR Shortman Ken K Purcell Anthony W AW Nicola Nicos A NA Zhang Jian-Guo JG Lahoud Mireille H MH
eLife 20201202
The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8<sup>+</sup> T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for regulation of Clec9A, reflecting the unique properties of Clec9A as a receptor specialized for delivery of antigens for cross-presentation. We reveal RNF41 is a negative regulator of Clec9A and ...[more]