Ontology highlight
ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC2562543 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Song Zhenlei Z Hsung Richard P RP Lu Ting T Lohse Andrew G AG
The Journal of organic chemistry 20071103 25
A detailed account on the stereoselective synthesis of the C1-C9 subunit of (+)-zincophorin is described here. This approach features the first application of a stereoselective inverse electron demand hetero-[4 + 2] cycloaddition of chiral allenamides in natural product synthesis. The C1-C9 subunit matches Cossy's intermediate, thereby constituting a formal total synthesis. In addition, details of an unusual urea-directed Stork-Crabtree hydrogenation observed during these efforts are also disclo ...[more]