CYP19 haplotypes increase risk for Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Huang R
PROVIDER: S-EPMC2564598 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Publications
CYP19 haplotypes increase risk for Alzheimer's disease.
Journal of medical genetics 20060801 8
Cytochrome P450 aromatase, an enzyme that catalyses the conversion of androgens to oestrogen, is expressed at high levels in the gonads and in the brain. Aromatase activity is increased in the nucleus basalis of Meynert during aging and in Alzheimer's disease (AD), making the gene (CYP19), at 15q21.1, a potential candidate risk factor. We examined 18 single nucleotide polymorphisms spanning the 5'-untranslated region and the entire coding region of CYP19 in 227 patients with AD and 131 control s ...[more]
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